More than 50% of people are affected by genetic variants in the methylation pathway.
The Advanced MethylDetox Profile
Methylation can play an important role in many chronic diseases. By understanding your genetics you can prevent and address these conditions with the right nutrition.
The MethylDetox Profile tests critical genes in the methylation pathway. By understanding your genes and how they impact methylation, you may prevent and address existing health problems with the right nutrition.
HSA / FSA accepted
Comprehensive testing for methylation and detoxification
The MethylDetox Profile gives more actionable information than MTHFR testing alone, giving you a more complete picture of your body’s methylation and detoxification. The MethylDetox profile includes suggestions for specific nutrient needs to address with practitioner guidance.
Standard MTHFR genotyping only evaluates folic acid metabolism. Scientific research reveals that a variety of genes are involved in maintaining methionine/homocysteine balance. Genetic variations (SNPs) in these important genes influence your methylation potential. Individual methylation is monitored using homocysteine levels. Important SNPs are included to evaluate your ability to methylate neurotransmitters, DNA, and toxins.
Who may benefit from this test?
Individuals with any of the following diagnoses or symptoms:
Cardiovascular Diseases e.g. hypertension, coronary artery disease, stroke
Neurological Disorders e.g. depression, dementia, Alzheimer’s disease, ADD/ADHD, ASD, chronic fatigue syndrome, migraine, insomnia
Metabolic Conditions e.g. metabolic syndrome, diabetes mellitus, kidney diseases, reduced ability to metabolize medications, multiple chemical sensitivity
Musculoskeletal Disorders e.g. osteoporosis
Eye Diseases e.g. macular degeneration
Cancer e.g. colorectal, breast, and others
The MTHFR gene’s purpose is to produce the important MTHFR enzyme in the body. This enzyme is an important part of maintaining optimal health. If the MTHFR gene has a variant, folate metabolism can be negatively impacted. Improper folate metabolism is implicated in many different diseases.
MTR codes for the enzyme, methionine synthase (MS). MS converts homocysteine to methionine using methylated vitamin B12. variants in this gene significantly impact homocysteine metabolism, which can increase the risk for a number of chronic conditions such as cardiovascular diseases, metabolic and neurological conditions and certain cancers.
The MTRR gene codes for the important enzyme, methionine synthase reductase (MSR). Methionine synthase reductase is required for the proper function of methionine synthase (see MTR). Both genes act together to convert homocysteine to methionine. variants can be involved with the development of cancers, Parkinson’s disease, depression, hypertension and many others.
COMT is the major gene involved in methylation. It plays an important role in a variety of disorders, including estrogen-induced cancers, Parkinson’s disease, depression, hypertension and many others. COMT is also necessary for maintaining the proper balance of neurotransmitters with SAMe obtained from methionine. Genetic variants in COMT can result in various neurological problems and has also been associated with Autism.
AHCY is the only enzyme known to convert S-Adenosylhomocysteine (AdoHcy) to homocysteine. It is crucial that AHCY immediately converts AdoHcy to homocysteine and adenine in order to maintain optimal methylation potential. Studies show a link between variants in this gene with poor methylation potential and severe myopathies, developmental delays and hypermethioninemia.
Homocysteine is an amino acid that is involved in maintaining the methionine cycle. Elevated homocysteine levels are well known risk factors for chronic disease, particularly cardiovascular, diabetes and neurodegenerative disorders